MicroRNAs in development and cancer
MicroRNAs in development and cancer [E-Book]
- London : Singapore : Imperial College Press ; World Scientific [distributor], 2011.
- 1 online resource (xv, 282 pages) : illustrations (some color)
- Molecular medicine and medicinal chemistry ; v. 1 .
- Molecular medicine and medicinal chemistry ; v. 1. .
Includes bibliographical references and index.
Introduction to gene regulation by small RNAs -- The emerging non-coding RNA world -- MicroRNAs in C. elegans development -- MicroRNAs in mammalian development -- MicroRNAs in hematopoietic development -- MicroRNAs function as tumor suppressor genes and oncogenes -- Simultaneous detection of primary, precursor and mature microRNAs by qPCR -- Single nucleotide polymorphisms in microRNAs and microRNA binding sites with roles in cancer -- MicroRNAs as potential diagnostics and therapeutics -- MicroRNA target prediction -- Non-coding RNAs in cancer: the other part of the story.
"MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer."--Page 4 of cover
English.
9781848163676 1848163673 1283143321 9781283143325 9786613143327 6613143324
101561909 DNLM 015829358 Uk
Small interfering RNA.
Cancer.
MicroRNA.
Tumor markers.
Genetic regulation.
MicroRNAs
Neoplasms--genetics
Neoplasms--therapy
Biomarkers, Tumor
Gene Expression Regulation
RNA, Small Interfering
Neoplasms
2011 F-738 QU 58.7
Includes bibliographical references and index.
Introduction to gene regulation by small RNAs -- The emerging non-coding RNA world -- MicroRNAs in C. elegans development -- MicroRNAs in mammalian development -- MicroRNAs in hematopoietic development -- MicroRNAs function as tumor suppressor genes and oncogenes -- Simultaneous detection of primary, precursor and mature microRNAs by qPCR -- Single nucleotide polymorphisms in microRNAs and microRNA binding sites with roles in cancer -- MicroRNAs as potential diagnostics and therapeutics -- MicroRNA target prediction -- Non-coding RNAs in cancer: the other part of the story.
"MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer."--Page 4 of cover
English.
9781848163676 1848163673 1283143321 9781283143325 9786613143327 6613143324
101561909 DNLM 015829358 Uk
Small interfering RNA.
Cancer.
MicroRNA.
Tumor markers.
Genetic regulation.
MicroRNAs
Neoplasms--genetics
Neoplasms--therapy
Biomarkers, Tumor
Gene Expression Regulation
RNA, Small Interfering
Neoplasms
2011 F-738 QU 58.7