Tuberculosis among people with HIV infection in the United Kingdom: opportunities for prevention? (Record no. 75399)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04526cam a2200397 4500 |
| 001 - CONTROL NUMBER | |
| control field | NMDX5901 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120401t2009 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Grant, A.D. |
| 240 ## - UNIFORM TITLE | |
| Uniform title | <a href="AIDS">AIDS</a> |
| 245 ## - TITLE STATEMENT | |
| Title | Tuberculosis among people with HIV infection in the United Kingdom: opportunities for prevention? |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | 2009 |
| 500 ## - GENERAL NOTE | |
| General note | NMUH Staff Publications |
| 500 ## - GENERAL NOTE | |
| General note | 32 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <span style="font-size: 8pt;"><span style="font-size: 10pt;"><strong><span style="mso-ansi-language:EN-US;mso-fareast-language:EL" lang="EN-US">OBJECTIVE: </span></strong><span style="mso-ansi-language:EN-US;mso-fareast-language:EL" lang="EN-US">Toinvestigate the incidence of, and risk factors for, tuberculosis among HIVclinic attendees in the United Kingdom.</span></span></span><span style="font-size: 10pt;"></span><p class="MsoNoSpacing" style="text-align:justify"><span style="font-size: 10pt;"><strong><span style="mso-ansi-language:EN-US;mso-fareast-language:EL" lang="EN-US">DESIGN AND METHODS: </span></strong><span style="mso-ansi-language:EN-US;mso-fareast-language:EL" lang="EN-US">Observationalcohort study of 27 868 individuals in the United Kingdom Collaborative HIVCohort collaboration, 1996-2005.</span></span></p><span style="font-size: 10pt;"></span><p class="MsoNoSpacing" style="text-align:justify"><span style="font-size: 10pt;"><strong><span style="mso-ansi-language:EN-US;mso-fareast-language:EL" lang="EN-US">RESULTS: </span></strong><span style="mso-ansi-language:EN-US;mso-fareast-language:EL" lang="EN-US">Amongindividuals not taking combination antiretroviral therapy (cART), tuberculosisincidence was considerably higher among individuals of black African vs. whiteor other ethnicities {incidence rates 9.9 [95% confidence intervals (CIs) 7.2,12.6], 2.5 [95% CI 1.8, 3.0] and 4.4 [95% CI 2.7, 6.0] episodes per 1000person-years, respectively}. Tuberculosis incidence decreased with time afterstarting cART; among black Africans, incidence was consistently higher andremained substantial (5.3 per 1000 person-years) at 24 months and longer afterstarting cART. The strongest independent risk factors for tuberculosis aftercART start were most recent CD4 cell count: adjusted rate ratios (aRR) 10.65(95% CI 6.11, 18.57), 3.40 (95% CI 2.05, 5.65), 1.77 (95% CI 1.06, 2.96) and1.84 (95% CI 1.09, 3.12) for individuals with CD4 cell counts less than 50,50-199, 200-349 and 350-499 cells/microl, respectively, compared with at least500 cells/microl; and black African vs. white ethnicity [aRR 2.93 (95% CI 1.89,4.54)]. HIV risk group, shorter time on cART, later calendar period andunsuppressed viral load were also independently associated with incident tuberculosis.</span></span><strong><span style="mso-fareast-language:EL"></span></strong></p><span style="font-size: 10pt;"></span><p class="MsoNoSpacing" style="text-align:justify"><span style="font-size: 8pt;"><span style="font-size: 10pt;"><strong><span style="mso-ansi-language:EN-US;mso-fareast-language:EL" lang="EN-US">CONCLUSIONS: </span></strong><span style="mso-ansi-language:EN-US;mso-fareast-language:EL" lang="EN-US">Tuberculosisincidence among people attending UK HIV clinics is substantial, particularlyamong those with non-white ethnicity and low CD4 cell counts, even afterstarting cART. Earlier HIV diagnosis is needed in order to implement interventionsto prevent tuberculosis; tuberculosis preventive therapy should be consideredin addition to cART.</span></span></span></p> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bansi, L. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ainsworth, J. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Anderson, J. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Delpech, V. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Easterbrook, P. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fisher, M. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gazzard, B. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gilson, R. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gompels, M. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hill, T. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Johnson, M. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Leen, C. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Orkin, C. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Phillips, A.N. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Porter, K. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Post, F. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walsh, J. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sabin, C.A. |
| 710 ## - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | United Kingdom Collaborative HIV Cohort Study Group |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://www.ncbi.nlm.nih.gov/pubmed/19770622">http://www.ncbi.nlm.nih.gov/pubmed/19770622</a> |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://journals.lww.com/aidsonline/Fulltext/2009/11270/Tuberculosis_among_people_with_HIV_infection_in.16.aspx">http://journals.lww.com/aidsonline/Fulltext/2009/11270/Tuberculosis_among_people_with_HIV_infection_in.16.aspx</a> |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection code | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Staff publications for NMDX | Ferriman information and Library Service (North Middlesex) | Ferriman information and Library Service (North Middlesex) | Shelves | 07/06/2022 | 07/06/2022 | 07/06/2022 | Book |