Pregnancy outcomes of women with pruritus, normal bile salts and liver enzymes: a case control study (Record no. 75771)

MARC details
000 -LEADER
fixed length control field 03179cam a2200229 4500
001 - CONTROL NUMBER
control field NMDX6607
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 120401t2008 xxu||||| |||| 00| 0 eng d
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Yoong, W.
240 ## - UNIFORM TITLE
Uniform title <a href="Acta Obstetricia et Gynecologica Scandinavica">Acta Obstetricia et Gynecologica Scandinavica</a>
245 ## - TITLE STATEMENT
Title Pregnancy outcomes of women with pruritus, normal bile salts and liver enzymes: a case control study
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc. 2008
500 ## - GENERAL NOTE
General note NMUH Staff Publications
500 ## - GENERAL NOTE
General note 87
520 ## - SUMMARY, ETC.
Summary, etc. &lt;span style="font-size: 8pt;"&gt;&lt;em style="line-height: 18.719999313354492px;"&gt;Background.&lt;/em&gt;&lt;span style="line-height: 18.719999313354492px;"&gt;&amp;nbsp;Obstetric cholestasis (OC) is associated with increased maternal and perinatal complications. Nevertheless, data on pregnancy outcomes of women who experience pruritus on a transient basis, but have normal bile salts and liver function tests (LFT) is scarce.&amp;nbsp;&lt;/span&gt;&lt;em style="line-height: 18.719999313354492px;"&gt;Methods.&lt;/em&gt;&lt;span style="line-height: 18.719999313354492px;"&gt;&amp;nbsp;The maternal and fetal outcomes of 144 women with pruritus but normal bile salts and LFTs were compared with the next delivered patient without itch who matched for age, ethnicity and parity.&amp;nbsp;&lt;/span&gt;&lt;em style="line-height: 18.719999313354492px;"&gt;Results.&lt;/em&gt;&lt;span style="line-height: 18.719999313354492px;"&gt;&amp;nbsp;The study and control groups had similar mean gestational ages at delivery and birth weights (&lt;/span&gt;&lt;em style="line-height: 18.719999313354492px;"&gt;p&lt;/em&gt;&lt;span style="line-height: 18.719999313354492px;"&gt;&amp;gt;0.05,&amp;nbsp;&lt;/span&gt;&lt;em style="line-height: 18.719999313354492px;"&gt;t&lt;/em&gt;&lt;span style="line-height: 18.719999313354492px;"&gt;&amp;nbsp;test). However, women with pruritus were more likely to have meconium-stained liqor, abnormal intrapartum cardiotocography and postpartum hemorrhage (PPH) (&lt;/span&gt;&lt;em style="line-height: 18.719999313354492px;"&gt;p&lt;/em&gt;&lt;span style="line-height: 18.719999313354492px;"&gt;&amp;lt;0.05, Fisher's exact test). There appears to be a trend towards a higher rate of instrumental delivery (&lt;/span&gt;&lt;em style="line-height: 18.719999313354492px;"&gt;p&lt;/em&gt;&lt;span style="line-height: 18.719999313354492px;"&gt;=0.07) in the study compared to the control group, although this did not reach statistical significance.&amp;nbsp;&lt;/span&gt;&lt;em style="line-height: 18.719999313354492px;"&gt;Conclusion.&lt;/em&gt;&lt;span style="line-height: 18.719999313354492px;"&gt;&amp;nbsp;This study suggests that women who have transient pruritus with normal bile salts and liver biochemistry appear to have higher intrapartum and postpartum complications and require increased vigilance. In order to evaluate this finding, further prospective studies will be required.&lt;/span&gt;&lt;br style="line-height: 18.719999313354492px;" /&gt;&lt;/span&gt;&lt;br /&gt;
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Memtsa, M.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Pun, S.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name West, P.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Loo, C.
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Okolo, S.
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="www.ncbi.nlm.nih.gov/pubmed/18382867">www.ncbi.nlm.nih.gov/pubmed/18382867</a>
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://ferriman.wufoo.com/forms/r7x3a7/">http://ferriman.wufoo.com/forms/r7x3a7/</a>
Holdings
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        Staff publications for NMDX Ferriman information and Library Service (North Middlesex) Ferriman information and Library Service (North Middlesex) Shelves 07/06/2022   07/06/2022 07/06/2022 Book
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