Firestein & Kelley's textbook of rheumatology

Biology of the normal joint -- Synovium -- Cartilage and chondrocytes -- Biology, physiology, and morphology of bone -- Muscle: anatomy, physiology, and biochemistry -- Biomechanics -- Regenerative medicine and tissue engineering -- Proteinases and matrix degradation -- Dendritic cells -- Mononuclear phagocytes -- Neutrophils -- T lymphocytes -- B cells -- Fibroblasts and fibroblast-like synoviocytes -- Mast cells -- Innate lymphoid cells and natural killer cells -- Platelets and megakaryocytes -- Principles of signaling -- The immunologic repercussions of cell death -- Innate immunity -- Adaptive immunity -- Autoimmunity and tolerance -- The microbiome in health and disease -- Metabolic regulation of immunity -- Genetics of rheumatic diseases -- Epigenetics of rheumatic diseases -- Complement system -- Prostaglandins, leukotrienes, and related compounds -- Chemokines and cellular recruitment -- Angiogenesis -- Cytokines -- Experimental models for rheumatoid arthritis -- Neuronal regulation of pain and inflammation -- Clinical research methods in rheumatic disease -- Economic impact of arthritis and rheumatic conditions -- Assessment of health outcomes -- Biomarkers in rheumatology -- Occupational and recreational musculoskeletal disorders -- Cardiovascular risk in inflammatory rheumatic disease -- Cancer risk in rheumatic diseases -- Introduction to physical medicine and rehabilitation -- Pregnancy and rheumatic diseases -- History and physical examination of the musculoskeletal system -- Ultrasound in rheumatology -- Evaluation of monoarticular and polyarticular arthritis -- Skin and rheumatic diseases -- The eye and rheumatic diseases -- Neck pain -- Shoulder pain -- Low back pain -- Hip and knee pain -- Foot and ankle pain -- Hand and wrist pain -- Temporomandibular joint pain -- Fibromyalgia -- Synovial fluid analyses, synovial biopsy, and synovial pathology -- Arthrocentesis and injection of joints and soft tissues -- Anti-nuclear antibodies -- Autoantibodies in rheumatoid arthritis -- Acute phase reactants -- Imaging in rheumatic diseases -- Therapeutic targeting of prostanoids -- Glucocorticoid therapy -- Traditional DMARDs: methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, and combination therapies -- Immunosuppressive drugs -- Anti-cytokine therapies -- Cell-targeted biologics and emerging targets: rituximab, abatacept, and other biologics -- Intra-cellular targeting agents in rheumatic disease -- Urate-lowering therapy -- Bisphosphonates -- Analgesic agents in rheumatic disease -- Nutrition and rheumatic diseases -- Evaluation and management of early undifferentiated arthritis -- Etiology of rheumatoid arthritis -- Pathogenesis of rheumatoid arthritis -- Clinical features of rheumatoid arthritis -- Treatment of rheumatoid arthritis -- Sjögren's syndrome -- Etiology and pathogenesis of spondyloarthritis -- Ankylosing spondylitis and other forms of axial spondyloarthritis -- Reactive arthritis -- Psoriatic arthritis --;Inflammatory bowel disease-associated arthritis and other enteropathic arthropathies -- Etiology and pathogenesis of systemic lupus erythematosus -- Clinical features of systemic lupus erythematosus -- Treatment of systemic lupus erythematosus -- Antiphospholipid syndrome -- Etiology and pathogenesis of systemic sclerosis -- Clinical features and treatment of scleroderma -- Inflammatory diseases of muscle and other myopathies -- Overlap syndromes -- Classification and epidemiology of systemic vasculitis -- Giant cell arteritis, polymyalgia rheumatica, and Takayasu's arteritis -- Anti-neutrophil cytoplasmic antibody-associated vasculitis -- Polyarteritis nodosa and related disorders -- Immune complex-mediated small vessel vasculitis -- Primary angiitis of the central nervous system -- Behçet's disease -- Pathogenesis of inflammasome-mediated diseases -- Etiology and pathogenesis of hyperuricemia and gout -- Clinical features and treatment of gout -- Calcium crystal disease: calcium pyrophosphate dihydrate and basic calcium phosphate -- Familial autoinflammatory syndromes -- Pathogenesis of osteoarthritis -- Clinical features of osteoarthritis -- Treatment of osteoarthritis -- Metabolic bone disease -- Proliferative bone diseases -- Osteonecrosis -- Relapsing polychondritis -- Heritable diseases of connective tissue -- Etiology and pathogenesis of juvenile idiopathic arthritis -- Clinical features and treatment of juvenile idiopathic arthritis -- Childhood-onset systemic lupus erythematosus, drug-induced lupus in children, and neonatal lupus -- Juvenile dermatomyositis, scleroderma, vasculitis, and autoimmune brain disease -- Bacterial arthritis -- Lyme disease -- Mycobacterial infections of bones and joints -- Fungal infections of bones and joints -- Rheumatic manifestations of HIV infection -- Viral arthritis -- Rheumatic fever and post-streptococcal arthritis -- Amyloidosis -- Sarcoidosis -- Hemochromatosis -- Hemophilic arthropathy -- Rheumatic manifestations of hemoglobinopathies -- IgG4-related disease -- Arthritis accompanying endocrine and metabolic disorders -- Rheumatic paraneoplastic syndromes: links between malignancy and autoimmunity -- Tumors and tumor-like lesions of joints and related structures -- Autoimmune complications of immune checkpoint inhibitors for cancer.

Through 10 outstanding editions, Kelley & Firestein's Textbook of Rheumatology has provided authoritative, in-depth guidance in rheumatology with an ideal balance of basic science and clinical application. The 11th Edition of this classic text continues this tradition of excellence, while keeping you abreast of recent advances in genetics and the microbiome, new therapies such as biologics and biosimilars, and other rapid changes in the field. It provides comprehensive, global coverage of all aspects of diagnosis, screening, and treatment in both adults and children, in a user-friendly, full color reference. Covers everything from basic science, immunology, anatomy, and physiology to diagnostic tests, procedures, and specific disease processes-including key data on therapeutic outcomes to better inform clinical decision making. Includes new chapters on Innate Lymphoid Cells and Natural Killer Cells, Pathogenesis of Inflammasome Mediated Diseases, Bisphosphonates, Ultrasound Evaluation of the Musculoskeletal System, and Evaluation of Monoarticular and Polyarticular Arthritis. Features 1,200 high-quality illustrations, including superb line art, quick-reference tables, and full-color clinical photographs. Shares the knowledge and expertise of internationally renowned scientists and clinicians, including new editor Dr. Gary Koretzky, specialist in immunology and rheumatology. Demonstrates the complete musculoskeletal exam in online videos, including abnormal findings and the arthroscopic presentation of diseased joints. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.