Autoantibodies

The concept of immunodiagnosis -- What is an autoantibody? -- Natural autoantibodies--homeostasis, autoimmunity, and therapeutic potential -- Molecular mimicry -- Affinity and avidity of autoantibodies -- Pathogenic mechanisms and clinical relevance of autoantibodies -- Predictive autoantibodies -- Antibodies against acute phase proteins -- Idiotypes and anti-idiotypes -- Introductory remarks for the diagnostic and therapeutic applications of monoclonal antibodies and various formats -- Human autoantibodies in urticaria, angioedema, and other atopic diseases -- Antineutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase -- Antineutrophil cytoplasmic antibodies with specificity for proteinase 3 -- Neutrophil-specific antinuclear and anticytoplasmic autoantibodies in chronic inflammatory diseases -- Antinuclear antibodies : general introduction -- Autoantibodies to survival of motor neuron (SMN) complex -- Antinucleolar antibodies as diagnostic markers in systemic autoimmune diseases -- Anti-U1RNP and -Sm antibodies -- Antibodies to rods and rings -- Antinucleosome autoantibodies -- Centromere autoantibodies -- DsDNA autoantibodies -- Histone autoantibodies -- Ku and Ki autoantibodies -- Neuronal nuclear autoantibodies, type 1 (Hu) -- Nuclear envelope protein autoantibodies/antilamin autoantibodies -- Antiribosomal P antibodies -- Ro/SSA autoantibodies -- Topoisomerase I (SCL 70) autoantibodies -- SS-B (La) autoantibodies -- Autoantibodies to GW/P bodies and components of the microRNA pathway -- Golgi complex and endosome antibodies -- Tumor-associated autoantibodies -- P53 autoantibodies -- Naturally occurring anti-HLA-E autoantibodies : evidences of HLA-Ia reactivity of anti-HLA-e antibodies -- Autoantibodies in therapeutic preparations of human intravenous immunoglobulin (IVIg) -- Cytoskeletal autoantibodies/antiactin antibodies -- Fibrillarin autoantibodies -- Fibronectin autoantibodies -- IFI16 autoantibodies -- Heat shock protein autoantibodies -- Antimyocardial autoantibodies (AMCA) -- Gastric autoantibodies -- Thyroid autoantibodies : thyroid peroxidase and thyroglobulin antibodies -- Thyrotropin receptor antibodies -- Glutamic acid decarboxylase antibody -- Antibodies to gonadal and adrenal tissue -- Humoral immunity in type 1 diabetes mellitus -- Autoantibody profile in inflammatory bowel disease -- Anti-intestinal goblet cell antibodies -- Antipancreatic autoantibodies -- Cryoglobulins and cryoglobulins secondary to hepatitis C virus infection -- Autoantibodies in autoimmune hepatitis -- Antitissue transglutaminase and antiendomysial antibodies -- Antigliadin and antideamidated gliadin peptide antibodies -- Liver cytosol antigen type 1 autoantibodies (LC-1), liver kidney microsomal autoantibodies (LKM), and liver microsomal autoantibodies (LM) -- Antimitochondrial antibodies -- Smooth muscle autoantibodies -- Coagulation factor autoantibodies -- Autoantibodies in heparin-induced thrombocytopenia -- Platelet autoantibodies -- Red cell autoantibodies -- Lymphocytotoxic autoantibodies -- Anti-phospholipase A2 receptor autoantibodies -- Glomerular basement membrane autoantibodies -- Nephritic factor autoantibodies -- IgA nephropathies

This book covers recent scientific advances, diagnostic techniques, and therapeutic technologies in the field of autoimmune diseases. Each chapter is focused on a single family of autoantibodies, providing historical notes, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value).