Trends over calendar time in antiretroviral treatment success and failure in HIV clinic populations.

By:

Bansi, L

Contributor(s): Publication details: 2010ISSN:

14642662

Uniform titles:

HIV Medicine

Online resources:

Summary: <div style="line-height: 17.999801635742188px;"><h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">OBJECTIVE:</h4>Effective antiretroviral therapy (ART) has transformed the care of people with HIV, but it is important to monitor time trends in indicators of treatment success and antic future changes.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">METHODS:</h4>We assessed time trends from 2000 to 2007 in several indicators of treatment success in the UK Collaborative HIV Cohort (CHIC) Study, and using national HIV data from the Health Protection Agency (HPA) we developed a model to project future trends.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">RESULTS:</h4>The proportion of patients on ART with a viral load <50 HIV-1 RNA copies/mL increased from 62% in 2000 to 84% in 2007, and the proportion of all patients with a CD4 count <200 cells/microL decreased from 21% to 10%. During this period, the number of patients who experienced extensive triple class failure (ETCF) rose from 147 (0.9%) to 1771 (3.9%). The number who experienced such ETCF and had a current viral load >50 copies/mL rose fromz 118 (0.7%) to 857 (1.9%). Projections to 2012 suggest sustained high levels of success, with a continued increase in the number of patients who have failed multiple drugs but a relatively stable number of such patients experiencing viral loads >50 copies/mL. Numbers of deaths are projected to remain low.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">CONCLUSIONS:</h4>There have been continued improvements in key indicators of success in patients with HIV from 2000 to 2007. Although the number of patients who have ETCF is projected to rise in the future, the number of such patients with viral loads >50 copies/mL is not projected to increase up to 2012. New drugs may be needed in future to sustain these positive trends.</div>

Holdings
Item type	Home library	Collection	Class number	Status	Date due	Barcode
Book	Ferriman information and Library Service (North Middlesex) Shelves	Staff publications for NMDX		Available

NMUH Staff Publications

<div style="line-height: 17.999801635742188px;"><h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">OBJECTIVE:</h4>Effective&nbsp;antiretroviral&nbsp;therapy (ART) has transformed the care of people with&nbsp;HIV, but it is important to monitor&nbsp;time&nbsp;trends&nbsp;in indicators of&nbsp;treatment&nbsp;success&nbsp;and antic future changes.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">METHODS:</h4>We assessed&nbsp;time&nbsp;trends&nbsp;from 2000 to 2007 in several indicators of&nbsp;treatment&nbsp;success&nbsp;in the UK Collaborative&nbsp;HIV&nbsp;Cohort (CHIC) Study, and using national&nbsp;HIV&nbsp;data from the Health Protection Agency (HPA) we developed a model to project future&nbsp;trends.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">RESULTS:</h4>The proportion of patients on ART with a viral load &lt;50&nbsp;HIV-1 RNA copies/mL increased from 62% in 2000 to 84% in 2007, and the proportion of all patients with a CD4 count &lt;200 cells/microL decreased from 21% to 10%. During this period, the number of patients who experienced extensive triple class&nbsp;failure&nbsp;(ETCF) rose from 147 (0.9%) to 1771 (3.9%). The number who experienced such ETCF and had a current viral load &gt;50 copies/mL rose fromz 118 (0.7%) to 857 (1.9%). Projections to 2012 suggest sustained high levels of&nbsp;success, with a continued increase in the number of patients who have failed multiple drugs but a relatively stable number of such patients experiencing viral loads &gt;50 copies/mL. Numbers of deaths are projected to remain low.<h4 style="margin: 0px 0.25em 0px 0px; text-transform: uppercase; float: left;">CONCLUSIONS:</h4>There have been continued improvements in key indicators of&nbsp;success&nbsp;in patients with&nbsp;HIV&nbsp;from 2000 to 2007. Although the number of patients who have ETCF is projected to rise in the future, the number of such patients with viral loads &gt;50 copies/mL is not projected to increase up to 2012. New drugs may be needed in future to sustain these positive&nbsp;trends.</div>

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