TY  - BOOK
AU  - Noebels,Jeffrey L.
AU  - Jasper,Herbert H.
AU  - Avoli,Massimo
AU  - Rogawski,Michael A.
TI  - Jasper's basic mechanisms of the epilepsies
T2  - Contemporary neurology series
SN  - 9780199842599 (electronic bk.)
PY  - 2012///
CY  - New York
PB  - Oxford University Press
KW  - Epilepsy
KW  - Congresses
KW  - Pathology, Cellular
KW  - Pathology, Molecular
N1  - Prev. ed.: Jasper's basic mechanisms of the epilepsies / editors, Antonio V. Delgado-Escueta ... [et al.]. 3rd. ed. c1999; Includes bibliographical references and index; Cover; Contents; Contributors; SECTION 1 INTRODUCTION; 1. THE NEXT DECADE OF RESEARCH IN THE BASIC MECHANISMS OF THE EPILEPSIES; SECTION 1: INTRODUCTION; SECTION 2: FUNDAMENTALS OF NEURONAL EXCITABILITY RELEVANT TO SEIZURES AND EPILEPSY; SECTION 3: MECHANISMS OF SEIZURE SUSCEPTIBILITY AND EPILEPTOGENESIS; SECTION 4: EPILEPSY GENES AND DEVELOPMENT; SECTION 5: EPILEPSY THERAPEUTICS; CLOSING SUMMARY; 2. HERBERT H. JASPER AND THE BASIC MECHANISMS OF THE EPILEPSIES; THE EARLY YEARS; WORK AT THE MONTREAL NEUROLOGICAL INSTITUTE; THE FOUNDING OF IBRO AND THE BME PROJECT; MOVING TO THE OTHER SIDE OF THE MOUNTAIN (MONT ROYAL, OF COURSE!)HERBERT JASPER'S LATE YEARS; APPENDIX: ORIGINAL CURRICULUM VITAE OF DR. H. JASPER, DATED APPROXIMATELY 1954; 3. WHY--AND HOW--DO WE APPROACH BASIC EPILEPSY RESEARCH?; WHAT DO WE MEAN BY "BASIC" RESEARCH?; WHAT CAN WE ACCOMPLISH BY ENGAGING IN BASIC RESEARCH?; WHY DO BASIC EPILEPSY RESEARCH?; HOW DO WE CHOOSE AND PRIORITIZE RESEARCH GOALS?; WHAT APPROACHES--CONCEPTUAL OR TECHNICAL--ARE LIKELY TO YIELD SIGNIFICANT RESULTS?; CONCLUDING THOUWGHTS; SECTION 2 FUNDAMENTALS OF NEURONAL EXCITABILITY RELEVANT TO SEIZURES AND EPILEPSY; 4. VOLTAGE-GATED NA[sup(+)] CHANNELS: STRUCTURE, FUNCTION, AND PATHOPHYSIOLOGYNA[sup(+)] CHANNEL SUBUNIT STRUCTURE; Na[sup(+)] CHANNEL GENES; MOLECULAR BASIS OF Na[sup(+)] CHANNEL FUNCTION; THREE-DIMENSIONAL STRUCTURE OF Na[sup(+)] CHANNELS; EXPRESSION, LOCALIZATION, AND FUNCTION OF Na[sup(+)] CHANNEL SUBTYPES IN THE NERVOUS SYSTEM; Na[sup(+)] CHANNEL PHARMACOLOGY; Na[sup(+)] CHANNEL AND EPILEPSY; GENETIC Na[sup(+)] CHANNELOPATHIES; FUTURE DEVELOPMENTS AND CHALLENGES; 5. POTASSIUM CHANNELS (INCLUDING KCNQ) AND EPILEPSY; K[sup(+)] CHANNELS: A DIVERSE SUPERFAMILY DERIVED FROM AN EXTRAORDINARILY USEFUL TEMPLATEKCNQ CHANNELS: FROM CHANNELOPATHY TO NOVEL THERAPY; KCNQ CHANNELS AND BEYOND: PROSPECTS FOR FUTURE POTASSIUM CHANNEL STUDIES IN EPILEPSY RESEARCH; 6. VOLTAGE-GATED CALCIUM CHANNELS IN EPILEPSY; CALCIUM CHANNEL NOMENCLATURE; CALCIUM CHANNEL BIOPHYSICAL PROPERTIES; CALCIUM CHANNELS AND EXCITABILITY; CALCIUM CHANNELS IN ABSENCE EPILEPSY; CALCIUM CHANNELS IN TEMPORAL LOBE/COMPLEX PARTIAL EPILEPSY; CALCIUM CHANNELS IN GENERALIZED CONVULSIVE SEIZURES; CONCLUSIONS; 7. HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) ION CHANNELOPATHY IN EPILEPSYHCN CHANNEL BIOPHYSICAL PROPERTIES; HCN CHANNEL EFFECTS ON NEURONAL EXCITABILITY; CONTRIBUTION OF HCN CHANNELS TO EPILEPSY; CONCLUSIONS; 8. PHASIC GABA[sub(A)]-MEDIATED INHIBITION; GABA[sub(A)]-MEDIATED IPSCS: PRESYNAPTIC REGULATION; DYNAMICS OF GABA TRANSIENTS IN THE SYNAPTIC CLEFT; GABA[sub(A)]-MEDIATED IPSCS: POSTSYNAPTIC REGULATION; FUTURE PERSPECTIVES; 9. TONIC GABA[sub(A)] RECEPTOR-MEDIATED SIGNALING IN EPILEPSY; GABA[sub(A)] RECEPTOR SUBTYPES UNDERLYING TONIC CONDUCTANCES; FUNCTIONS OF TONIC GABA[sub(A)] RECEPTOR CURRENTS
N2  - H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where
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