Essential immunology for surgeons [E-Book]

Previously published as: The Immunological basis of surgical science and practice, 1992.

Includes bibliographical references and index.

Print version record.

There has been a huge increase in the knowledge and understanding of the immunological processes involved in surgical practice in recent years. Anaesthesiologists and intensive care physicians are increasingly recognising the significant derangements of immune function in the critically ill patient and the possible therapeutic approaches to manage such patients (including new approaches in transplantation rejections, novel vaccination strategies in cancer treatment, as well as abetter understanding of the beneficial effects of standard chemotherapy). Written by recognised experts in their field.

Abbreviations and acronyms -- 1. Basic immunology -- Introduction -- Overview of immunology -- Introduction -- Innate and adaptive immunity -- Clusters of differentiation and monoclonal antibodies -- Cytokines, chemokines, and signalling -- Central and peripheral lymphoid organs -- lymphocyte recirculation -- Clonal selection -- Immunogens, antigens, and adjuvants -- Recognition elements, cells, and receptors in adaptive immunity -- Major histocompatibility complex -- Antigen processing and presentation: adhesion molecules and costimulation -- T cells, receptors, and effectors: CD4[sup(+)] Th -- 1. Th -- 2. and Th -- 17. CD4[sup(+)] Tregs and CD8[sup(+)] CTLs -- B cells, receptors, and antibodies -- Recognition events and functionality of the integrated immune system: in vivo -- Introduction -- Antigen entry and responses via the natural portal of the GIT -- Mucosal-associated lymphoid tissue -- Parental injection of antigen -- Superantigen -- Physiological benefits of the effector immune response -- Introduction -- Complement system of proteins -- Effector cells and receptors -- Vaccination -- Immune regulation and modulation -- Introduction -- Immune regulation and innate immunityApoptosis and autophagy -- Immune tolerance: central and peripheral tolerance -- Activation-induced cell death -- Autoimmunity -- Immune modulation -- Immunopathology and tissue damage, immune deficiency and immunotherapeutics -- Immunopathological processes: hypersensitivity (types I-IV) and tissue damage -- Allergy, immunotherapy, and new vaccines -- Primary (congenital) and secondary (acquired) immune deficiencies (including HIV/AIDS) -- HIV, AIDS, and the surgeon -- Monoclonals and other biological therapies (including immunoglobulin replacement) -- References and further reading -- 2. Trauma and tissue injury -- Host defences and the metabolic response to injury -- Trauma background -- Trauma and multiple organ failure -- Multiple organ failure and mesenteric lymph -- Host defences and the critical care setting -- Background -- Epidemiology -- Inflammatory mediators -- Signalling molecules -- Pattern recognition receptors -- Cellular immunity -- Conclusion -- Trauma and coagulation -- Haemostasis and fibrinolysis -- Acute coagulopathy of trauma -- Coagulation and the immune system -- Transfusion-related acute lung injury -- Host defences and the metabolic response to injury in childrenBackground -- Development of the immune system -- Injury-induced inflammation in children -- Therapeutic modulation of host defences -- Decreasing inflammation -- Enhancement of the immune system -- Gut modulation -- Summary and conclusions -- 3. Transplantation immunology -- Background -- Introduction and historical perspective -- Terminology -- Tissues and histocompatibility -- Introduction -- Immunological considerations in organ transplantation -- The HLA system -- HLA matching -- Tissue typing -- Immunology of transplant rejection -- Introduction -- Contribution of innate immunity.

WorldCat record variable field(s) change: 650