Practical transfusion medicine

Preceded by Practical transfusion medicine / edited by Michael F. Murphy, Derwood H. Pamphilon, Nancy M. Heddle. 4th ed. 2013.

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Title Page; Table of Contents; List of Contributors; Preface; 1 Introduction; Blood Donation Worldwide; Changing Landscape of Transfusion Risks; Immunohaematology; Clinical Use of Blood Components: Evolution Based on Evidence; Urgent Transfusion; Patients Requiring Chronic Transfusion Support; Obstetric, Neonatal and Paediatric Transfusion Medicine; Haemostasis and Transfusion; Cellular Therapies, Transplantation, Apheresis; The Future; Conclusion; References; Part I: Basic Principles of Immunohaematology; 2 Essential Immunology for Transfusion Medicine; Cellular Basis of the Immune Response

B‐Cell Activation and T‐Cell‐Dependent Antibody FormationHumoral Immune Response; Antibody Effector Functions; Red Blood Cell Antibodies Illustrating the Above Principles; Antibody and Complement‐Mediated Blood Cell Destruction; Clinical Aspects Related to Alloimmunisation Against Blood Cell Antigens; References; Further Reading; 3 Human Blood Group Systems; Introduction; The ABO System; The Rh System; Other Blood Group Systems; Biological Significance of Blood Group Antigens; References; Further Reading; 4 Human Leucocyte Antigens; Introduction; HLA Class I Genes; HLA Class II Genes

Genetic Organisation and Expression of HLA Class II GenesExpression of HLA Molecules; Genetics; Function of HLA Molecules; Identification of HLA Gene Polymorphism; Formation of HLA Antibodies; Detection of HLA Antibodies; Clinical Relevance of HLA Antigens and Antibodies; HLA and Disease; References; Further Reading; 5 Platelet and Neutrophil Antigens; Antigens on Platelets and Granulocytes; Human Platelet Antigens; Human Neutrophil Antigens; References; Further Reading; 6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion; Introduction

Determining the Recipient's ABO Group and Screening for Unexpected AntibodiesCrossmatching Techniques; Selection of Red Cells for Transfusion; Selection of Platelets and Plasma Components; References; Further Reading; Part II: Complications of Transfusions; 7 Investigation of Acute Transfusion Reactions; Introduction; Understanding the Clinical Presentation and Differential Diagnosis; General Approach for Investigation and Treatment of Acute Transfusion Reactions; Algorithm; References; Further Reading; 8 Haemolytic Transfusion Reactions; Definition of a Haemolytic Transfusion Reaction

Pathophysiology of HTRsAcute HTRs; Delayed HTRs; Acute Haemolysis from ABO‐Incompatible Platelet Transfusions; References; Further Reading; 9 Febrile and Allergic Transfusion Reactions; Introduction; Febrile Non‐haemolytic Transfusion Reactions; Allergic Transfusion Reactions; References; 10 Lung Injury and Pulmonary Oedema After Transfusion; Definition; Incidence, Outcomes and Recipient Risk Factors; Clinical Manifestations; Differential Diagnosis; Pathogenesis; Lung Histology; Types of Blood Components That Can Cause TRALI; Mitigation Strategies; Patient Management; References

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Includes bibliographical references and index.