000			02081cam a2200193 4500
001			NMDX7421
008			120401t1999 xxu||||| |||| 00| 0 eng d
100			_aDavidson, N.G.
240			_aCancer Chemotherapy and Pharmacology
245			_aFILM (5-fluorouracil, ifosfamide, leucovorin and mitomycin C), an alternative chemotherapy regimen suitable for the treatment of advanced breast cancer in the 'out-patient' setting
260			_c1999
500			_aNMUH Staff Publications
500			_a44
520			_a<span style="font-size: 10pt;">FILM, a combination of 5-fluorouracil (5-FU) 750 mg/m(2), ifosfamide 1 g/m(2), leucovorin 200 mg/m(2) and mitomycin C 6 mg/m(2) (alternate cycles), was administered to 24 chemo-naive patients with inoperable disease, locally advanced or metastatic. Up to 6 x 3-weekly cycles of FILM were administered on an out-patient basis. Responses included 8 patients in complete remission (CR) and 12 showing a partial response (PR) (83%). Following analysis of these results, the FILM regimen was introduced as a standard out-patient protocol at the <span class="highlight">North Middlesex</span> Hospital, United Kingdom. A further 66 patients have been treated in this setting. Retrospective analysis of these data confirm the trial results and allow conclusions regarding tolerability, toxicity, duration of response and survival to be drawn from a total cohort of 90 patients. A total of 524 cycles have been administered. Nineteen cycles (4%) were delayed owing to slow recovery of white blood cells (WBC), but no dose reductions were necessary. Five blood transfusions were required for anaemia. The most frequent non-haematological toxicities included nausea, vomiting and fatigue. Of 80 patients treated for inoperable or locally advanced disease, 56 (70%) remain in remission, and 69 (86%) remain alive after 5 years.</span>
700			_aWoods, J.
700			_aSnooks, S.
856			_uhttps://www.ncbi.nlm.nih.gov/pubmed/10602905
856			_uhttps://link.springer.com/content/pdf/10.1007%2Fs002800051111.pdf
999			_c76324 _d76324