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037 _a109234:109280
_bElsevier Science & Technology
_nhttp://www.sciencedirect.com
060 4 _a2007 K-948
060 4 _aQU 450
_bF944m 2008
072 7 _aMED
_x030000
_2bisacsh
049 _aMAIN
100 1 _aFrudakis, Tony Nick.
245 1 0 _aMolecular photofitting :
_bpredicting ancestry and phenotype using DNA
_c
_h[E-Book]
260 _aAmsterdam ;
_aBoston :
_bElsevier/Academic Press,
_c2008.
300 _a1 online resource (xiv, 695 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
520 _aIn the field of forensics, there is a critical need for genetic tests that can function in a predictive or inferential sense, before suspects have been identified, and/or for crimes for which DNA evidence exists but eye-witnesses do not. Molecular Photofitting fills this need by describing the process of generating a physical description of an individual from the analysis of his or her DNA. The molecular photofitting process has been used to assist with the identification of remains and to guide criminal investigations toward certain individuals within the sphere of prior suspects. Molecular Photofitting provides an accessible roadmap for both the forensic scientist hoping to make use of the new tests becoming available, and for the human genetic researcher working to discover the panels of markers that comprise these tests. By implementing population structure as a practical forensics and clinical genomics tool, Molecular Photofitting serves to redefine the way science and history look at ancestry and genetics, and shows how these tools can be used to maximize the efficacy of our criminal justice system. * Explains how physical descriptions of individuals can be generated using only their DNA * Contains case studies that show how this new forensic technology is used in practical application * Includes over 100 diagrams, tables, and photos to illustrate and outline complex concepts.
505 0 _aChapter 1. Forensic DNA Analysis: from Modest Beginnings to Molecular Photofitting, Genics, Genetics, Genomics and the Pertinent Population Genetics Principles -- Chapter 2. Ancestry and Admixture -- Chapter 3. Biogeographical Ancestry Admixture Estimation -- Theoretical Considerations -- Chapter 4. Biogeographical Ancestry Admixture Estimation -- Practicality and Application -- Chapter 5. Characterizing Admixture Panels -- Chapter 6. Apportionment of Autosomal Diversity with Continental Markers -- Chapter 7. Apportionment of Autosomal Diversity with Sub-Continental Markers -- Chapter 8. Indirect Methods for Phenotype Inference -- Chapter 9. Direct Method of Phenotype Inference -- Chapter 10. The First Case Studies of Molecular Photofitting -- Chapter 11. The Politics and Ethics of Admixture Analysis and Molecular Photofitting -- Chapter 11. The Politics and Ethics of Admixture analysis and Molecular Photofitting.
504 _aIncludes bibliographical references (pages 661-676) and index.
588 0 _aPrint version record.
546 _aEnglish.
590 _aWorldCat record variable field(s) change: 650
650 0 _aForensic genetics.
650 0 _aDNA fingerprinting.
650 0 _aPhenotype.
650 1 2 _aDNA Fingerprinting
_xmethods
650 1 2 _aGenetics, Population
_xmethods
650 2 2 _aForensic Genetics
_xmethods
650 2 2 _aPhenotype
650 2 _aDNA Fingerprinting
856 4 0 _uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=205616
_yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
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