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008 141021s2014 ne ob 001 0 eng d
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019 _a894171500
_a911047828
020 _a9780124105492
_q(PDF ebook)
020 _a0124105491
_q(PDF ebook)
035 _a593413
_b(N$T)
035 _a(OCoLC)894609030
_z(OCoLC)894171500
_z(OCoLC)911047828
037 _a785184
_bMIL
037 _aE2BB10A8-0A1F-4050-87DE-3E59F3556520
_bOverDrive, Inc.
_nhttp://www.overdrive.com
060 4 _aWL 140
_bM7178r 2015
072 7 _aHEA
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049 _aMAIN
130 0 _aMolecular and genetic basis of neurological and psychiatric disease.
245 1 0 _aRosenberg's molecular and genetic basis of neurological and psychiatric disease
_c
_h[E-Book]
250 _aFifth edition.
264 1 _aAmsterdam :
_bAcademic Press,
_c2014.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
588 0 _aCIP data; item not viewed.
500 _aPreceded by Molecular and genetic basis of neurologic and psychiatric disease / editors, Roger N. Rosenberg [and others]. 4th ed. c2008.
504 _aIncludes bibliographical references and index.
505 0 _aFront Cover; Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease; Copyright; Dedications; Contents; Preface to the Fifth Edition; Contributors; Section I: General Concepts and Tools; Chapter 1: Mendelian, Non-Mendelian, Multigenic Inheritance, and Epigenetics; Introduction; Mendelian traits; Mendel's Laws; Chromosomes and Genes; Mendelian Inheritance; Molecular Pathomechanisms of Mutations; Factors That Modify Classic Mendelian Inheritance Patterns; New Mutations, Mosaicism, and Somatic Mutations; Penetrance and Expressivity; Repeat expansion disorders.
505 8 _aNon-mendelian inheritanceMitochondrial Inheritance; Imprinting; Uniparental Disomy; Imprinting, UPD, and Genetic Disorders; Chromosomal and genomic disorders; Aneuploidy; lsochromosomes; Translocations; Intrachromosomal Rearrangements; Mechanisms for Formation of Chromosomal Rearrangements; Nonallelic homologous recombination (NAHR); Nonhomologous end joining (NHEJ); Fork stalling and template switching/microhomology-mediated break-induced replication (FoSTeS/MMBIR); How Chromosomal Rearrangements Confer Phenotypes; Assays for Chromosomal and Genomic Disorders; Multigenic inheritance.
505 8 _aDigenic InheritanceModifier Genes; Complex traits; Genetic Features of Complex Traits; Assessing Variation in the Human Genome; Genetic Variation and Complex Traits; Examples of Susceptibility Genes for Complex Traits; Epigenetics; DNA Methylation and Hydroxymethylation; Histone Modifications and Higher Order Chromatin Remodeling; Noncoding RNA Regulation; The human genome: High-throughput technologies; Conclusions; References; Chapter 2: Genotype-Phenotype Correlations; Introduction; Single phenotype: Multiple genes; Single gene: Multiple phenotypes; Neuronal/cellular selective vulnerability.
505 8 _aHighly variable systemic phenotypesPenetrance and age of onset; Conclusion and future directions; References; Chapter 3: Immunogenetics of Neurological Disease; Introduction; Epidemiological evidence for genetic susceptibility; Genetics of MS: Family-based investigations; The role of major histocompatibility complex genes; Other immune-related genes; The environment and immune-related genes; Conclusion; References; Chapter 4: Pharmacogenomic Approaches to the Treatment of Sporadic Alzheimer Disease using Cholinomimetic Agents; Introduction; Genetic risk factors and sporadic alzheimer disease.
505 8 _aGenetic risk factors, cholinergic dysfunction, and alzheimer diseaseApoE4 and cholinomimetic drugs in alzheimer disease; Experimental drugs and their relationship to the apoE4 allele; Acetylcholinesterase and butyrylcholinesterase genetic variants in dementia; Acknowledgements; References; Chapter 5: Application of Mouse Genetics to Human Disease: Generation and Analysis of Mouse Models; Generation and Analysis of Mouse Models; Introduction; Creating mouse models; Transgenesis; Gene Targeting; Random Mutagenesis; Phenotypic analysis of mouse models; Summary; References.
520 _a" ... With this new edition the three key markets, research scientists, clinicians, and genetic counselors will all continue to benefit from the content. The research community will find great value in the coverage of genomics, animal models, and diagnostic methods along with a a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations. And genetic counselors will find this a comprehensive tutorial reference on the latest advances in the science, with links to genetic testing for specific diseases.
590 _aWorldCat record variable field(s) change: 650
650 0 _aNervous system
_xDiseases
_xMolecular aspects.
650 0 _aNervous system
_xDiseases
_xGenetic aspects.
650 0 _aMolecular neurobiology.
650 0 _aNeurogenetics.
650 0 _aGenetic disorders.
650 1 2 _aNervous System Diseases
_xgenetics
650 2 2 _aMental Disorders
_xgenetics
650 2 2 _aGenetic Diseases, Inborn
700 1 _aRosenberg, Roger N.,
_eeditor.
700 1 _aPascual, Juan M.,
_eeditor.
856 4 0 _uhttps://search.ebscohost.com/login.aspx?custid=ns123844&authtype=ip,shib&direct=true&scope=site&db=nlebk&db=nlabk&AN=593413
_yKingston Hospital NHS Foundation Trust OpenAthens account holders click here for access
938 _aEBL - Ebook Library
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938 _aEBSCOhost
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938 _aProQuest MyiLibrary Digital eBook Collection
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