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MicroRNAs in development and cancer [E-Book]

Contributor(s):

Slack, Frank J

Series: Molecular medicine and medicinal chemistry ; v. 1.Publication details: London : Imperial College Press ; Singapore : World Scientific [distributor], 2011.Description: 1 online resource (xv, 282 pages) : illustrations (some color)Content type:

text

Media type:

computer

Carrier type:

online resource

ISBN:

9781848163676
1848163673
1283143321
9781283143325
9786613143327
6613143324

Subject(s):

NLM classification:

2011 F-738
QU 58.7

Online resources:

Kingston Hospital NHS Foundation Trust OpenAthens account holders click here for access

Contents:

Introduction to gene regulation by small RNAs -- The emerging non-coding RNA world -- MicroRNAs in C. elegans development -- MicroRNAs in mammalian development -- MicroRNAs in hematopoietic development -- MicroRNAs function as tumor suppressor genes and oncogenes -- Simultaneous detection of primary, precursor and mature microRNAs by qPCR -- Single nucleotide polymorphisms in microRNAs and microRNA binding sites with roles in cancer -- MicroRNAs as potential diagnostics and therapeutics -- MicroRNA target prediction -- Non-coding RNAs in cancer: the other part of the story.

Summary: "MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer."--Page 4 of cover

Holdings
Item type	Home library	Class number	URL	Status	Date due	Barcode
Electronic book	Stenhouse Library		Link to resource	Available

Includes bibliographical references and index.

"MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer."--Page 4 of cover